Product Details
High Quality Chinese Manufacturer supply 2689-68-1 METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE
- Molecular Formula: C6H8O3S
- Molecular Weight: 160.194
- Appearance/Colour: Slight yellow to yellow crystalline powder
- Melting Point: 37-38 °C
- Boiling Point: 248.4 °C at 760 mmHg
- PKA: 10.52±0.20(Predicted)
- Flash Point: 116.7 °C
- PSA： 68.67000
- Density: 1.31 g/cm3
- LogP: 0.09150
METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE(Cas 2689-68-1) Usage
InChI:InChI=1/C6H8O3S/c1-9-6(8)4-2-10-3-5(4)7/h4H,2-3H2,1H3
2689-68-1 Relevant articles
-
Hromatka et al.
, p. 1520,1525 (1973)
-
An improved procedure for the preparation of 3-carbomethoxy-4-oxotetrahydrothiopyran, 2- and 4-carbomethoxy-3-oxotetrahydrothiophene
Liu, Hsing-Jang,Ngooi, Teng Ko
, p. 437 - 439 (1982)
An improved procedure for the preparatio...
HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF
-
Paragraph 0598; 0636; 0640-0642, (2021/11/04)
The invention relates to kinase inhibito...
The novel method to synthesis of cantharidin intermediate
Tan, Chunbin,Liu, Xiaoling,Du, Hongfei
, p. 271 - 276 (2019/07/31)
Sulfur-containing dehydrocantharidin(SD)...
SYNTHESIS OF CANTHARIDIN
-
, (2019/04/27)
The invention provides synthetic methods...
SEMICONDUCTING POLYMERS AND TERNARY BLENDS THEREOF
-
Paragraph 0084; 0089, (2016/08/17)
Semiconducting photovoltaic polymers and...
2689-68-1 Process route
-
-
7400-45-5
dimethyl-3-thiaadipate
-
-
2689-69-2
methyl tetrahydrothiophen-3-one-2-carboxylate
-
-
2689-68-1,99328-39-9
methyl 4-oxotetrahydrothiophene-3-carboxylate
| Conditions | Yield |
|---|---|
|
With
sodium methylate;
In
methanol;
for 0.666667h;
Heating / reflux;
|
54%
|
|
With
methanol; sodium;
for 0.666667h;
Heating / reflux;
|
54%
|
|
With
sodium methylate;
In
diethyl ether;
for 3h;
Heating;
|
18%
44% |
|
With
lithium methanolate;
In
toluene;
at 70 - 110 ℃;
for 18.5h;
|
33%
|
|
With
sodium hydride;
In
1,2-dimethoxyethane;
at -40 ℃;
Inert atmosphere;
|
-
-
7400-45-5
dimethyl-3-thiaadipate
-
-
2689-68-1,99328-39-9
methyl 4-oxotetrahydrothiophene-3-carboxylate
| Conditions | Yield |
|---|---|
|
With
pyridine;
In
toluene;
at 80 ℃;
for 2.5h;
|
80%
|
|
With
lithium methanolate;
In
methanol; toluene;
at 70 - 110 ℃;
|
53.7%
|
|
dimethyl-3-thiaadipate;
With
sodium methylate;
In
tetrahydrofuran;
at 20 ℃;
for 2.08333h;
Reflux;
With
hydrogenchloride;
In
tetrahydrofuran; water;
|
39%
|
|
dimethyl-3-thiaadipate;
With
sodium methylate;
In
tetrahydrofuran;
at 20 ℃;
for 2.08333h;
Reflux;
With
hydrogenchloride;
In
tetrahydrofuran; water;
Cooling with ice;
|
39%
|
|
With
sodium hydride;
In
tetrahydrofuran;
for 5h;
Heating / reflux;
|
35%
|
|
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
for 7h;
Reflux;
|
35%
|
|
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
for 7h;
Reflux;
|
35%
|
|
With
sodium methylate; toluene;
|
|
|
With
acetic acid;
In
methanol; water;
|
|
|
Multi-step reaction
with
2
steps
1: methanol; lithium / 7 h / 20 °C / Inert atmosphere; Reflux
2: hydrogenchloride / water / pH Ca.
5
With
hydrogenchloride; methanol; lithium;
In
water;
|
2689-68-1 Upstream products
-
7400-45-5
dimethyl-3-thiaadipate
-
2365-48-2
Methyl thioglycolate
-
292638-85-8
acrylic acid methyl ester
-
16002-29-2
dimethyl thiodiglycolate
2689-68-1 Downstream products
-
75532-25-1
2,2,4,4-tetrahydrothiophene-3,4-dicarboxylic acid anhydride
-
102750-23-2
3-(2,5-bis-benzenesulfonylamino-phenyl)-4-oxo-tetrahydro-thiophene-3-carboxylic acid methyl ester
-
1003-04-9
Tetrahydrothiophen-3-one
-
39978-14-8
methyl 3-amino-4-thiophenecarboxylate hydrochloride
METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE
CAS:2689-68-1
Purity:99%
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